Bird Flu H5N1 - Overview and New Concerning Mutations | Public Health

Bird Flu H5N1 (HPAI) Virus has been continuing to evolve with more human cases and a growing concern from the larger infectious disease community about new human cases. In this video, we dive into new mutations found in a teenager infected with Bird Flu and what it may mean for the risk of an outbreak in the future.

Overview: origin of Bird Flu, historic cases, spread into cattle, human cases, viral presence in milk, population seropositivity, and more).

Canadian teenager without previous exposure critically ill with Bird Flu.

Canadian teenager found to have viral mutation PB2 E627K and also found in one other Texas man.

What is PB2 in Bird Flu viruses?

PB2 E627K has evolved in past in a human infected with Bird Flu.

PB2 E627K present in 70% of cases in previous Chinese outbreak that had ~40% mortality and responsible for increased replication, pathogenicity, and spread.

PB2 mutations may help virus infect human lung epithelial cells.

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YouTube Video:

https://www.youtube.com/watch?v=TVhN_BIBPfY