Acute Respiratory Distress Syndrome (ARDS) Advanced - Pathophysiology | Clinical Medicine

In this podcast, we explore the advanced pathophysiology of Acute Respiratory Distress Syndrome (ARDS), diving deep into the molecular mechanisms and cellular processes that drive the progression of this life-threatening condition. Understanding ARDS at the pathophysiological level is critical for effective management and treatment in clinical settings.

Introduction to inflammatory response, diffuse alveolar damage, capillary alveolar barrier, matrix repair, profibrotic response

Exudative phase including endothelial and epithelial damage, inflammatory response, proteinaceous leak, loss of surfactant, micro thrombi

Proliferative phase including neutrophil clearance, matrix repair, alveolar repair, type 1 and 2 pneumocytes, removal proteinaceous fluid

Fibrosing phase including fibroblast proliferation, hyaline membranes, profibrotic pathway

Heterogeneity of ARDS, CT findings, VQ mismatch, shunting, diffusion coefficients, and dead space

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YouTube Video:

https://www.youtube.com/watch?v=-gNGMTCPEuc