WhiteBoard Medicine - Emergency And Critical Care

#221 Transfusion Products Explained | PRBCs, Platelets, FFP, PCC, and Cryoprecipitate

Packed Red Blood Cells (PRBCs), Platelets, Fresh Frozen Plasma (FFP), Prothrombin Complex Concentrate (PCC), and Cryoprecipitate are the foundational transfusion products used to treat anemia, bleeding, and coagulopathy. Understanding what each product does and how to choose the right one is essential for safe and effective patient care.
In this episode, we provide a practical, high-yield overview of transfusion products, focusing on indications, clinical decision-making, and real-world use rather than memorization. This audio-first discussion is designed for learners and clinicians who want a clear framework they can apply at the bedside.
Topics covered include:
What PRBCs, platelets, FFP, PCC, and cryoprecipitate contain
Indications for each transfusion product
Transfusion thresholds and treatment targets
Choosing the right product for anemia, bleeding, and coagulopathy
Coagulation product selection and reversal strategies
Risks, complications, and transfusion reactions
How these products are used in trauma, ICU, and emergency care
This episode is intended for medical students, residents, nurses, paramedics, pharmacists, and practicing clinicianslooking for a concise, clinically focused review of transfusion medicine.
Link to YouTube video: https://www.youtube.com/watch?v=C4J-fNd5hFs
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
 
⚠️ Disclaimer
This podcast is intended for educational purposes only and does not constitute medical advice. Clinical decisions should always be made based on individual patient circumstances, current evidence, institutional protocols, and consultation with appropriate medical professionals. Transfusion practices and thresholds may vary by setting and evolve over time.
The views expressed are those of the presenter and do not represent the policies or positions of any affiliated institutions.

#220 Coagulation Products Explained: FFP, PCC, and Cryoprecipitate

Fresh Frozen Plasma (FFP), Prothrombin Complex Concentrate (PCC), and Cryoprecipitate are core coagulation products used in bleeding and coagulopathy management — but knowing which product to choose and when is essential for safe, effective care.
In this episode, we break down the key differences between FFP, PCC, and cryoprecipitate, focusing on composition, indications, and clinical decision-making rather than slide-based teaching. This audio-first discussion is designed to help you make smarter transfusion choices at the bedside.
Topics covered include:
What FFP, PCC, and cryoprecipitate contain
Indications for each coagulation product
When PCC is preferred over FFP for anticoagulation reversal
When cryoprecipitate is indicated for low fibrinogen
Practical dosing and transfusion considerations
Risks, complications, and transfusion reactions
How these products fit into trauma, ICU, and emergency care
This episode is intended for medical students, residents, nurses, paramedics, pharmacists, and practicing cliniciansseeking a clear, high-yield overview of coagulation product selection they can listen to on the go.
Link to YouTube video: https://www.youtube.com/watch?v=phYo-7X3CgU
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
⚠️ Disclaimer
This podcast is intended for educational purposes only and does not constitute medical advice. Clinical decisions should always be made based on individual patient circumstances, current evidence, institutional protocols, and consultation with appropriate medical professionals. Transfusion practices and thresholds may vary by setting and evolve over time.
The views expressed are those of the presenter and do not represent the policies or positions of any affiliated institutions.

#219 Cryoprecipitate Transfusion Explained | Components, Indications, Dosing, and Fibrinogen

Cryoprecipitate transfusion is a targeted therapy used to correct hypofibrinogenemia and specific coagulation factor deficiencies in bleeding patients. In this episode, we break down when to give cryoprecipitate, how to dose it, and what fibrinogen targets matter most in everyday clinical practice.
This discussion covers:
What cryoprecipitate is and what it contains
Indications for cryoprecipitate transfusion
Fibrinogen thresholds and treatment targets
Cryoprecipitate use in trauma, obstetrics, liver disease, and massive transfusion
Dosing strategies and practical administration tips
Risks, complications, and transfusion reactions
How cryoprecipitate compares to fibrinogen concentrate and fresh frozen plasma
This episode is designed for medical students, residents, nurses, paramedics, pharmacists, and practicing clinicianslooking for a concise, high-yield overview they can listen to on the go.
Link to YouTube video: https://www.youtube.com/watch?v=SnIaikeZlyU
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
⚠️ Disclaimer
This podcast is intended for educational purposes only and does not constitute medical advice. Clinical decisions should always be made based on individual patient circumstances, current evidence, institutional protocols, and consultation with appropriate medical professionals. Transfusion practices and thresholds may vary by setting and evolve over time.
The views expressed are those of the presenter and do not represent the policies or positions of any affiliated institutions.

#218 Platelet Transfusion Explained | Indications, Thresholds, and Transfusion Triggers

Platelet transfusion is a common intervention in thrombocytopenia, bleeding, and peri-procedural care — but knowing when to transfuse, what thresholds to use, and how to balance risks and benefits is critical.
In this episode, we walk through a practical, evidence-based approach to platelet transfusion decision-making, focusing on real-world clinical scenarios rather than slide-based teaching.
Topics covered include:
What platelet transfusions are and how they work
Indications for platelet transfusion
Platelet count thresholds for bleeding, procedures, and prophylaxis
Medical vs surgical platelet transfusion considerations
Risks, complications, and transfusion reactions
Practical tips for ordering and administering platelets
This episode is designed for medical students, residents, nurses, paramedics, pharmacists, and practicing clinicianswho want a clear, high-yield overview they can listen to on the go.
Link to YouTube video: https://www.youtube.com/watch?v=o8kamtx0WRk
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
⚠️ Disclaimer
This podcast is intended for educational purposes only and does not constitute medical advice. Clinical decisions should always be made based on individual patient circumstances, current clinical guidelines, and institutional protocols. Transfusion thresholds and practices may vary by setting and evolve over time.
The views expressed are those of the presenter and do not represent the policies or positions of any affiliated institutions.

#217 Prothrombin Complex Concentrate (PCC) Explained | Components, Indications, Dosing, and Safety

Prothrombin Complex Concentrate (PCC) is a powerful, targeted coagulation therapy used in urgent bleeding and anticoagulation reversal. In this episode, we walk through what PCC is, when to use it, how to dose it, and what safety considerations matter most in real-world clinical practice.
This audio-focused discussion covers:
What Prothrombin Complex Concentrate (PCC) contains
Common indications, including warfarin and vitamin K antagonist reversal
Key differences between 3-factor and 4-factor PCC
Practical dosing strategies
Risks, contraindications, and thrombotic concerns
How PCC compares to fresh frozen plasma (FFP)
This episode is designed for medical students, residents, nurses, paramedics, pharmacists, and practicing clinicianslooking for a clear, practical overview of PCC without slides or visuals.
Whether you’re reviewing on the go or reinforcing clinical decision-making, this episode provides a concise, high-yield explanation of one of the most important modern coagulation products.
Link to YouTube video: https://www.youtube.com/watch?v=9e0gjK5Ic_0
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
This content is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Clinical decisions should always be made based on individual patient circumstances, institutional protocols, and consultation with appropriate medical professionals.
The information discussed reflects general principles of medical practice and may not apply to all clinical situations. Dosing, indications, and management strategies may vary by institution and evolve over time. Listeners are encouraged to verify information with current guidelines and local policies before applying it in clinical practice.
The views expressed are those of the presenter and do not represent the policies or positions of any affiliated institutions.

#216 Shock Explained: An ICU Starter Guide to Physiology, Vasopressors, and Management

Shock is a life-threatening state of circulatory failure that requires rapid recognition and a strong understanding of underlying physiology. In this episode, we provide a clear, structured ICU starter guide to shock, focusing on how and why patients deteriorate and how to intervene effectively at the bedside.
We begin with the core physiology of shock and mechanisms of impaired tissue perfusion, then walk through the major shock states—hypovolemic, cardiogenic, distributive, and obstructive shock. From there, we discuss practical assessment of perfusion using clinical exam findings, lactate, and capillary refill time, as well as how mechanical ventilation can influence hemodynamics.
The episode also includes a focused overview of vasopressors and inotropes, common pitfalls in shock management, and a framework for ongoing reassessment and escalation of care. This is a physiology-first, clinically grounded discussion designed for emergency medicine and critical care clinicians looking to build or reinforce a systematic approach to shock management.
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
Link to YouTube video: https://www.youtube.com/watch?v=QQmn0jD4alw 
Podcast Disclaimer
This podcast is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The information discussed reflects general medical concepts and may not apply to individual patients or clinical situations. Clinical decisions should always be made in the context of a licensed healthcare professional’s judgment, institutional protocols, and current clinical guidelines. The views expressed are those of the hosts and do not necessarily represent the views of any affiliated institutions.

#215 Septic Shock Explained: Diagnosis, Management, and Common Mistakes

Septic shock is one of the most common and deadly emergencies encountered in critical care, yet early missteps in diagnosis and management can dramatically worsen outcomes. In this episode, we walk through septic shock step by step, focusing on how to recognize it, how to manage it effectively, and the most common mistakes clinicians make along the way.
We start by reviewing the physiology of septic shock and how it differs from uncomplicated sepsis, then move into practical bedside diagnosis and perfusion assessment. From there, we discuss fluid resuscitation, vasopressor selection and timing, source control, and reassessment, highlighting where well-intentioned treatments often fail.
This episode is designed as a practical, physiology-based guide for emergency medicine and critical care clinicians who want a structured framework for managing septic shock and avoiding common pitfalls that impact patient outcomes.
 
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
Link to YouTube video: https://www.youtube.com/watch?v=4duvp0evQ-8 
Podcast Disclaimer
This podcast is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The information discussed reflects general medical concepts and may not apply to individual patients or clinical situations. Clinical decisions should always be made in the context of a licensed healthcare professional’s judgment, institutional protocols, and current clinical guidelines. The views expressed are those of the hosts and do not necessarily represent the views of any affiliated institutions.

#214 ECMO Explained: VA-ECMO, VV-ECMO, and When to Use Each

Extracorporeal membrane oxygenation (ECMO) is one of the most complex and powerful tools in critical care—but also one of the most misunderstood. In this episode, we break down ECMO step by step, focusing on VA-ECMO, VV-ECMO, how they work, and when to use each configuration.
We start with the fundamentals of ECMO physiology and circuit components, then walk through veno-arterial (VA) ECMO for cardiac failure and veno-venous (VV) ECMO for severe respiratory failure. Along the way, we highlight key indications, hemodynamic effects, common pitfalls, and complications clinicians need to recognize at the bedside.
This episode is designed as a practical, physiology-based guide for emergency medicine and critical care clinicians who want a clear mental model for ECMO decision-making—whether you’re encountering it for the first time or looking to solidify your understanding.
 
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
Link to YouTube video: https://www.youtube.com/watch?v=tpZKcvJiuvc
Podcast Disclaimer
This podcast is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The information discussed reflects general medical concepts and may not apply to individual patients or clinical situations. Clinical decisions should always be made in the context of a licensed healthcare professional’s judgment, institutional protocols, and current clinical guidelines. The views expressed are those of the hosts and do not necessarily represent the views of any affiliated institutions.
 

#213 Most Common Mistakes in Septic Shock Management | Emergency & Critical Care

Septic shock management is complex, and many poor outcomes stem from preventable management errors rather than delayed recognition. In this episode, we break down the most common mistakes clinicians make when managing septic shock, using a physiology-driven framework relevant to both the emergency department and ICU.
We discuss pitfalls related to fluid resuscitation, delayed or inappropriate vasopressor use, treating mean arterial pressure instead of tissue perfusion, missed right ventricular failure, and delays in source control. Throughout the episode, we emphasize reassessment and escalation strategies that help avoid persistent hypoperfusion and organ dysfunction.
This episode is designed for emergency medicine physicians, intensivists, residents, and trainees looking for a practical, bedside-focused approach to septic shock management beyond rigid protocols.
Link to YouTube Video: https://www.youtube.com/watch?v=LktPBGHtn10
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
Disclaimer: This content is for educational purposes only and does not constitute medical advice. Clinical decisions should be made by licensed healthcare professionals using their clinical judgment, institutional protocols, and current evidence. Whiteboard Medicine assumes no responsibility for clinical outcomes.

#212 Metformin-Associated Lactic Acidosis (MALA) Explained | Symptoms, Pathophys, Diagnosis & Management

Metformin-associated lactic acidosis (MALA) is rare, but when it occurs, it carries significant morbidity and mortality. In this episode, we walk through a practical, clinician-focused approach to recognizing and managing MALA in the emergency department and ICU.
We review the pathophysiology behind metformin-related lactic acidosis, common risk factors and precipitating conditions, and the clinical features that should raise concern for MALA. We also discuss the diagnostic approach, key laboratory findings, and management strategies, including supportive care and considerations for dialysis.
This episode is designed for emergency medicine and critical care clinicians, residents, and trainees who want a clear mental model for evaluating unexplained lactic acidosis in patients taking metformin.
Link to YouTube Video: https://www.youtube.com/watch?v=4jmgU9u9Ba8
📚 Download the PDF study guide for this video: 👉 https://www.patreon.com/c/WhiteBoardMedicine 
Patreon members get access to mini-courses, study guides, practice questions, ad-free videos, and in-depth educational discussions designed for emergency and critical care clinicians.
Disclaimer: This content is for educational purposes only and does not constitute medical advice. Clinical decisions should be made by licensed healthcare professionals using their clinical judgment, institutional protocols, and current evidence. Whiteboard Medicine assumes no responsibility for clinical outcomes.